Disinfectants

Virucidal efficacy of your disinfectant

The recent hygiene requirements to fight the Covid-19 pandemic have highlighted the importance of disinfectants. ViruSure can perform virucidal testing of your agent following the DIN, Robert Koch Institute (RKI) and German Association for the Control of Virus Diseases (DVV) guidelines.

The measurement of virus inactivation in a homogeneous suspension is not necessarily considered to represent conditions encountered in routine daily practice. It does however allow statements about the efficiency of the tested disinfectant to be made and makes possible a comparison of the effectiveness of different disinfectants under a defined set of conditions.

The selection of viruses is determined by the intended application area of the disinfectant. Viruses can be broadly separated into two groups, either enveloped (those containing a lipid bilayer surrounding the virus core) and non-enveloped (i.e. those containing no membrane, and where the genome is bound up in a protein shell). In general, non-enveloped viruses demonstrate a higher resistance to disinfection.

Disinfectant evaluation studies at ViruSure have been specifically designed to comply with the guidelines established by the DIN, RKI and DVV, and include all the necessary internal controls to allow full and transparent interpretation of the inactivation potential. A number of the model viruses are available for disinfection studies at ViruSure.

Virus Selection for Disinfectant Evaluation Studies

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Target Viruses
Example Model Viruses
Genome
Size (nm)
Envelope
Viruses for use with disinfectants with limited spectrum of virucidal activity
Disinfectant effective only against enveloped viruses
Proxviruses
Vaccinia virus
dsDNA
200-400
Yes
Pestiviruses
Bovine viral diarrhoea virus
ssRNA
50-70
Yes
Viruses for use with disinfectants with virucidal activity
Disinfectants which additionally can also inactivate non-enveloped viruses
Andenoviruses
Andenovirus type 5
dsDNA
70-80
No
Polyomaviruses
Simian virus type 40
dsDNA
40-50
No
Picornaviruses
In anticipation of the WHO goal of polio virus eradication, the replacement of polio virus by HAV is accepted
Hepatitis A virus (Polio virus)
ssRNA
28-30
No
Parvovirusest
Highly resistant virus
Porcine parvovirus
ssRNA
18-22
No

Please contact us for a tailored virus selection for your studies.

Not all disinfectants must be effective against both enveloped and non-enveloped viruses, and depending on the field of application, the model viruses against which the disinfectant should be tested are to be selected accordingly (see table).

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