Virus Permissivity Studies

To determine virus susceptibility of your unique cell expression system

If you are using an alternative expression system and you are interested in its susceptibility to virus infection, ViruSure can assist you with virus permissivity studies using a wide range of different viruses to check if they are permissive to your producer cells.

Based on an initial literature search ViruSure would suggest a panel of model viruses to check the permissivity of your producer cells. Cells will be incubated with these viruses and infection will be monitored by determining the titre at different time points

Example Panel of Viruses for Use in Virus Permissivity

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Model Viruses
Taxonomy
Rationale for Inclusion
Bovine Viral Diarrhoea Virus (BVDV)
Flaviviridae
Fetal bovine serum (FBS) used in cell culture may be contaminated with viruses including BVDV. Flaviviruses can infect both human and animal cells
Hepatitis A Virus (HAV)
Picornaviridae
Picornaviruses cause a wider range of illnesses and can infect both human and animal cells
Murine Leukemia Virus (MuLV)
Retroviridae
Retroviruses cause an extremely wide range of responses in infected animal hosts. Most replication-competent retroviruses are not cytopathic and the infection of cells has remarkably little impact on their replication or physiology
Porcine Parvovirus (PPV)
Parvoviridae
Parvoviruses are some of the most stable viruses and have been detected in a wide range of species
Pseudorabies Virus (PRV)
Herpesviridae
Herpesviruses have been detected in a wide range of species, and can infect both human and animal cells
Reovirus type 3 (REO)
Orthoreoviridae
Reoviruses have been detected in a wide range of species, and can infect both human and animal cells
Simian Virus 40 (SV40)
Polyomaviridae
Polyomaviruses have the potential to cause tumors in animals. Polyomaviruses can infect both human and animal cells
Sindbis virus (SBV)
Togaviridae
Togaviruses are important pathogens transmitted by insects and known to cause human and animal disease

VERO (a cell line from African Green Monkey) is a highly permissive cell line. Therefore, it is used in our in vitro adventitious agent test.

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